Nanoscale spatial genomics for aging and disease

See the genome in its native context

We develop spatial genomics tools to study the genome and transcriptome directly inside cells and tissues, at the nanoscale.

Understand how inflammation leaves a lasting mark

Using these tools alongside single-cell genomics, we investigate how chronic inflammation reshapes the epigenome during aging and contributes to age-associated disease.

Explore whether damaged epigenome can be repaired

We test targeted epigenetic interventions, including CRISPR-based genome editing and epigenetic reprogramming, to explore whether harmful changes can be reversed.

Aging and epigenomic memory

Aging involves not only cellular damage, but also changes in epigenomic memory. By studying genome organization and gene regulation in their native spatial context, we aim to understand how inflammatory and aging-related signals become embedded in the genome over time—and how that process might be reversed.

Our long-term goal is to build a framework for making the genome more resilient to inflammation, aging, and age-related disease.